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Cell Manipulation System Based on a Self-Calibrating Silicon Micro Force Sensor Providing Capillary Status Monitoring

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5 Author(s)
Tobias Beutel ; Institute of Microtechnology, Technische Universität Braunschweig, Braunschweig, Germany ; Nelson Ferreira ; Anne Balck ; Monika Leester-Schadel
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In this paper, a system for cell manipulation is presented. A two axis stage is arranged on an inverted microscope to place cells in focus. Cell manipulation can thereby be observed while the system automatically runs force controlled measurements. A high precision linear motor moves a force sensor, which has been equipped with a stimulation tool, e.g., a micro capillary for cell injection. The sensor is made up of silicon and consists of a membrane with a boss structure, which enables measurements as low as 120 \mu{\rm N} . For the first tests, an injection capillary is mounted on the topside, while the backside is fixed to a printed circuit board with an integrated air pressure connection. Air pressure was applied under the membrane because the glass capillaries with outer diameters of at least 1 \mu{\rm m} do not allow calibration via other force sensors. This setup provides a self-calibration of the mounted sensor system, before the measurements of the occurred forces on the cells during the penetration of the capillary. Using the 3-D force measurement capability of the sensor, the system features a unique end-effector status monitoring.

Published in:

IEEE Sensors Journal  (Volume:12 ,  Issue: 10 )