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The concept of entrepreneurship and the idea of entrepreneurship education are not novel. Entrepreneurship education at the university level, is mostly taught in business schools. Entrepreneurial skills are for every student. This empirical study investigates the role of case-based learning (CBL) in relation to entrepreneurial skills development in MIS multidisciplinary undergraduate courses at the University of Nicosia. The study addresses the organizational, pedagogical and practical challenges associated with immersing students in CBL activities that expose them to entrepreneurial thinking. A case study approach was used, collecting qualitatively data through observations and focus groups with students and reports from the lecturer. A suggested framework is presented where CBL approach is used to develop entrepreneurial skills.