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In this review, we illustrate EDA's potential for high-impact contributions in biodesign using a case study. Fast integral-equation solvers are used widely to analyze electromagnetic fields in circuits and packaging and can be leveraged to understand and design the electrostatic interactions between biological molecules. Fast simulations of Maxwell's equations enable accurate prediction of system behavior prior to fabrication, and are therefore essential tools for rapid design cycles. To name just one use, fast solvers are critical for timing analysis, i.e., understanding how parasitic interactions between on-chip interconnects delay signal propagation. High-speed circuits possess millions of transistors and interconnects, making fast, accurate simulation an economic necessity to avoid costly product delays and failures.