Referenced Items are not available for this document.
We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 G Ω resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were implemented on 630 × 440 μm2 using a 0.5- μm 3-metal 2-poly CMOS process. Each channel consumes 1.5 mW of power from a 3.3 V supply. We measured the characteristics of an artificial lipid bilayer similar to the ones used in DNA sequencing experiments via nanopores.
Published in:
Biomedical Circuits and Systems, IEEE Transactions on
(Volume:6
,
Issue:
2
)
Date of Publication: April 2012
- Page(s):
- 111 - 119
- ISSN :
- 1932-4545
- INSPEC Accession Number:
- 12674825
- Digital Object Identifier :
- 10.1109/TBCAS.2011.2182512
- Product Type:
- Journals & Magazines
- Date of Publication :
- 14 February 2012
- Date of Current Version :
- 19 April 2012
- Issue Date :
- April 2012
- Sponsored by :
- IEEE Circuits and Systems Society
About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies
A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2013 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.
