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In this review, we will focus on advances in several imaging modalities, and their relationships to specific disease states. In the first section we discuss the role of 4-D ultrasound in estimating cardiac function, and how such information may be combined with additional data for assessment of ischemia. Section II describes the role of multimodal imaging and segmentation in computer-aided treatment planning for liver cancer. In Section III, we explore new methodologies in the fusion of PET data with complementary images from MRI and CT, with applications in the leading types of cancer. Finally, in Section IV, recent advances in measuring cerebral blood volume are described.