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Comparing to three-axis machines, Multi-axis machines perform more efficient and accurate machining. It has become an important tool for modern engineering industries and is widely used in aerospace, shipbuilding, automobile, plastic, mold, and optical industries. In this paper, a Universal Kinesiology modelinging developed as a feasible alternative to the accurate measures that are only used to separate machine frames. This universal modelinging is then used to check the feasibility of the two rotational joints within the kinesiology chain of three main types of Multi-axis CNC machine. This universal modelinging is very helpful applied to the design of multi-axis machine.