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Artificial bile acid receptor in E.coli

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7 Author(s)
Han Zhong Ke ; Dept. of Biol. Sci. & Eng., Univ. of Sci. & Technol. Beijing, Beijing, China ; Jing Ren ; Xiao Lan Li ; Huai Han Cai
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Using lacI DNA-binding domain and LXRbeta ligand-binding domain, we made an artificial bile acid receptor which can regulate expression of target gene within a natural lacI operon. As proof of principle, we demonstrate that regulation of bacteria gene expression by host eukaryocyte metabolites is achievable using chimeric nuclear receptors. Through directed molecular evolution, a harmonious signal network regulating metabolism of both prokaryocytes and their host eukaryocytes in the digestive tract is feasible.

Published in:

Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on

Date of Conference:

24-26 June 2011

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