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In this letter we compare the throughput performance of multiuser MIMO-OFDM systems operating in time-variant scenarios. The system employes packet-based transmissions and the receiver is twofold-iterative implementing multiuser detection, channel estimation and soft single-user decoding. Different combinations in terms of multiple-access techniques (time division, frequency division, and space division) and modulation schemes (BPSK and QPSK) are compared. Large-size constellations with interfering users in space-division multiple access (SDMA) are preferable in high-SNR range.