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A Beacon of Light

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5 Author(s)
Hsin-Chih Yeh ; He is currently a postdoctoral researcher in the Center for Integrated Nanotechnologies at Los Alamos National Laboratory. ; Jaswinder Sharma ; Jason J. Han ; Jennifer S. Martinez
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We demonstrated controlled conversion of DNA/Ag NCs between bright and dark states and designed a new molecular probe, NCB, for homogeneous detection of nucleic acid targets. Not relying on Forster energy transfer as the fluorescence on/off switching mechanism, NCBs have the potential to reach an ultrahigh S/B ratio in molecular sensing. Since the fluorescence enhancement is caused by intrinsic nucleobases, our detection technique is simple, inexpensive, and compatible with commercial DNA synthesizers. Here, we demonstrated that a palette of NCB light-up colors can be produced from the same origin by employing different proximal sequences. We also showed that the NC-nucleation sequences capable of achieving strong red fluorescence enhancement share a common 5'-C3NNNNNC4 motif.

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IEEE Nanotechnology Magazine  (Volume:5 ,  Issue: 2 )