Referenced Items are not available for this document.
We demonstrated controlled conversion of DNA/Ag NCs between bright and dark states and designed a new molecular probe, NCB, for homogeneous detection of nucleic acid targets. Not relying on Forster energy transfer as the fluorescence on/off switching mechanism, NCBs have the potential to reach an ultrahigh S/B ratio in molecular sensing. Since the fluorescence enhancement is caused by intrinsic nucleobases, our detection technique is simple, inexpensive, and compatible with commercial DNA synthesizers. Here, we demonstrated that a palette of NCB light-up colors can be produced from the same origin by employing different proximal sequences. We also showed that the NC-nucleation sequences capable of achieving strong red fluorescence enhancement share a common 5'-C3NNNNNC4 motif.
Published in:
Nanotechnology Magazine, IEEE
(Volume:5
,
Issue:
2
)
Date of Publication: June 2011
- Page(s):
- 28 - 33
- ISSN :
- 1932-4510
- INSPEC Accession Number:
- 12060097
- Digital Object Identifier :
- 10.1109/MNANO.2011.940951
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 09 June 2011
- Issue Date :
- June 2011
- Sponsored by :
- IEEE Nanotechnology Council
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