Skip to Main Content
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE's Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Over recent years, much attentions have focused on the hydroxysteroid dehydrogenases (HSD) subfamily members belonging to the aldo-keto reductase (AKR) 1C subfamily (AKR1C). This is due to the ability of AKR1C enzymes to modify androgens, estrogens, progesterone and prostaglandins (PGs) in a tissue-specific manner, regulating the activity of nuclear receptors and other downstream effects. In the study, we describe a cluster of the HSDs gene family on human chromosome 10. These include four previously reported human HSD genes (AKR1-C1, -C2, -C3, and AKR1-C4) and a more distantly related AKR1E2. We also compared the five human and the ninty murine isoforms in their phylogeny. Our results demonstrate that at least AKR1E2 should reside in the AKR gene cluster and was clearly the most divergent of the four AKR1C proteins.