By Topic

Simulating the impact of the transmural extent of acute ischemia on the electrocardiogram

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Wilhelms, M. ; Inst. of Biomed. Eng., Karlsruhe Inst. of Technol. (KIT), Karlsruhe, Germany ; Dossel, O. ; Seemann, G.

During acute cardiac ischemia, electrophysiological properties of the affected tissue are altered in the subendo-cardium firstly. If the occlusion worsens, the effects spread transmurally. Diagnosis of cardiac ischemia, which should be improved by computer simulations, is based on shifts of the ST segment. In this work, we simulated heterogeneous ischemic regions with varying transmural extent. The excitation propagation and ECGs were calculated for the different setups. We showed that ST segment polarity can be dependent on the transmural extent of the ischemic region. In case of subendocardial ischemia, short action potentials were initiated in the ischemic zone causing a slight transmural gradient of the transmembrane voltage. Therefore, the ST segment was depressed in leads near the ischemic region in the chosen case. During transmural ischemia, this gradient showed in the opposite direction from epicardium to endocardium leading to ST segment elevation.

Published in:

Computing in Cardiology, 2010

Date of Conference:

26-29 Sept. 2010