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Effective decision support assist greatly in many control and management processes. Many business processes may be easily formalized and simulated, allowing automated assistance in decision making. The paper describes research on current decision support systems with the self-developed system BPsim.DSS, based on multi-agent simulation of resource conversion processes, extended with additional functionality, including agent coalitions consideration, simulation experiment design, and assistance in model design. Process definition apparatus allows such approach to be applied to various kinds of business processes in many spheres of life. Some examples of deployment within different kinds of enterprises are provided, including economical effect estimation.