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Keynote: DNA-based molecular devices

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1 Author(s)
Reif, J.H. ; Dept of Comput. Sci., Duke Univ., Durham, NC, USA

We overview recent work in the field of DNA-based autonomous biomolecular devices. We particularly emphasize molecular assemblies and molecular devices that are (i) self-assembled: that is they assemble into DNA nanostructures in one stage without explicit external control, (ii) programmable: the tasks the molecular devices execute can be modified without an entire redesign and (ii) autonomous: they operate without external mediation (e.g. thermal-cycling). We describe recent experimental progress in DNA-based autonomous biomolecular devices that achieve: 2D patterning, computation, amplified sensing, and molecular nano-scale transport. These have taken the technology from a state of intriguing possibilities into demonstrated capabilities of quickly increasing scale, and we describe a number of very promising applications in the biomedical industry.

Published in:

Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on

Date of Conference:

3-5 Feb. 2011

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