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A novel co-regularization framework for active learning is proposed for hyperspectral image classification. The first regularizer explores the intrinsic multi-view information embedded in the hyperspectral data. By adaptively and quantitatively measuring the disagreement level, it focuses only on samples with high uncertainty and builds a contention pool which is a small subset of the overall unlabeled data pool, thereby mitigating the computational cost. The second regularizer is based on the “consistency assumption” and designed on a spatial or the spectral based manifold space. It serves to further focus on the most informative samples within the contention pool by penalizing rapid changes in the classification function evaluated on proximally close samples in a local region. Such changes may be due to the lack of capability of the current learner to describe the unlabeled data. Incorporating manifold learning into the active learning process enforces the clustering assumption and avoids the degradation of the distance measure associated with the original high-dimensional spectral features. One spatial and two local spectral embedding methods are considered in this study, in conjunction with the support vector machine (SVM) classifier implemented with a radial basis function (RBF) kernel. Experiments show excellent performance on AVIRIS and Hyperion hyperspectral data as compared to random sampling and the state-of-the-art SVMSIMPLE.