Cloud Technologies for Bioinformatics Applications

Executing large number of independent jobs or jobs comprising of large number of tasks that perform minimal intertask communication is a common requirement in many domains. Various technologies ranging from classic job schedulers to the latest cloud technologies such as MapReduce can be used to execute these "many-tasks” in parallel. In this paper, we present our experience in applying two cloud technologies Apache Hadoop and Microsoft DryadLINQ to two bioinformatics applications with the above characteristics. The applications are a pairwise Alu sequence alignment application and an Expressed Sequence Tag (EST) sequence assembly program. First, we compare the performance of these cloud technologies using the above applications and also compare them with traditional MPI implementation in one application. Next, we analyze the effect of inhomogeneous data on the scheduling mechanisms of the cloud technologies. Finally, we present a comparison of performance of the cloud technologies under virtual and nonvirtual hardware platforms.