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In traditional, economic construction is usually the only object in city's development. But today, because of the change of international and domestic environments and the challenge of city's sustainable development, the harmonious construction of economic, social and ecological is the new object of city development. In this paper, to take Hezhou, a less developed city in Guangxi Province, as a case study, the quantitative analysis and horizontal comparison on city's resources and environment, economic development and industrial structure is submitted. Meanwhile, the paper gives a comprehensive analysis of the macro context and concerns of the opportunities and challenges of city development. Aimed at the harmonious development of economic, social and ecological, the paper proposes the city's development strategy. Thought the study on Hezhou, the paper tries to explore a mode of city development strategic guidance for less developed regions, to achieve the city's sustainable development.