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Aimed at the faults of low level of geological exploration in Dingxiang district in south of Anbui Provence, an integrated finding mineral model was constructed after studying the mineralization regularity of copper-polymetallic deposits. According to the model, collected and analyzed the comprehensive information from geology, geophysics, geochemical and remote sensing. Then six key prediction variables were chosen based on spacial analysis function of GIS. Made the grid thematic layers of the variables, gave their corresponding weights according to the importance in metallogenic diagnosis. Some perspective zones were enclosed by view of the metallogenic favorability. Result indicates that combining the integrated finding mineral model with GIS can effectively make use of expert knowledge, and has the characteristics of simple calculation, reliable results. So it can provide decision-making basis for further exploration.