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Simulation based computational analysis is a key approach for system design and evaluation in many domains. These computation processes are often complex and experience-based, requiring domain scientists and engineers to deal with heterogeneous simulation models and applications in an integrated manner. As domain users employ simulations for increasingly sophisticated studies, management of the computation tasks and avalanche of legacy models becomes a barrier to decision making and high quality research. In this paper, we present a semantic approach to simulation based computation process modeling and management in transportation domain. The workflow representation of processes, semantic descriptions of underlying models and applications and processing these information form the basis of our approach. We have implemented this approach in a prototype system and used it in real-world applications.