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Worm detection and defense is still a critical mission for worm researchers. This paper presents an architecture for active detection and defense against the internet worms based on multi and mobile agents. This Paper depends on the cooporation between the agents to achieve zero day worms' detection in addition to detecting the well known worms. The results show that the used approach based on the proposed architecture can detect worm propagation in an infection rate less than 0.18 % of vulnerable nodes.