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Two-dimensional echocardiographic images of left ventricle are analyzed to characterize quantitatively spatio-temporal heterogeneity of regional wall motion in norm and ischemic heart disease. A negative correlation between the regional heterogeneity and the global ejection fraction is revealed. Regional heterogeneity is shown to increase significantly in patients with ischemic heart disease compared to normal subjects. A special contribution of the apex is identified, and a diagnostic index of regional wall motion abnormality is suggested.