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We have designed, fabricated, and characterized a set of displacement based micromechanical force sensors. These sensors combine high force resolution (50-500 pN) with large force measurement range (100 nN - 1 Â¿N) and have highly linear force-displacement characteristics. In addition, we have established a novel scheme to avoid capillary forces during the immersion and removal of these sensors from aqueous environments that make them highly suitable for biological studies. As a demonstration of their versatility, these sensors are used to measure the mechanical response of embryonic Drosophila (fruit fly) axons in vivo.