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We proposed a fabrication method for multiscale transparent arteriole and capillary vessel models and demonstrated the fabrication of microchannels with circular cross sections Â¿10 - 500 Â¿m. First, we demonstrated fabrication of Â¿10 - 500 Â¿m arteriole and capillary vessel block models using photolithography. The circularity of fabricated Â¿10, 50, and 500 Â¿m microchannels were 84.0%, 61.5%, and 82.3%, respectively. Flow experiments demonstrated that these channels had no leakage. Next, we proposed a fabrication method for Â¿100 - 500 Â¿m arteriole membrane models, which connect larger membrane models and smaller block models. These models were prepared with grayscale lithography and a wax and PVA (polyvinyl alcohol) mixture material. The proposed approach overcame the brittleness of a previous sacrificial model fabricated by ink jet rapid prototyping. The membrane model had a circular cross section with a channel circularity of 90%. Finally, we succeeded in making transparent membranous and block arteriole model with which we can simulate blood circulation.
Date of Conference: 10-15 Oct. 2009