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4-Hydroxyphenylacetic acid (4-HPA) can inhibit monophenolase (IC50=0.79 mM) and activate diphenolase of mushroom tyrosinase with its increasing concentrations. The activation kinetics, analyzed by Lineweaver-Burk plots, indicated 4-HPA to be a competitive and uncompetitive mixed-type activator of diphenolase when L-DOPA was used as substrate. 4-HPA can not only inhibit the oxy form but also activate the met form of mushroom tyrosinase.
Date of Conference: 11-13 June 2009