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Spatially selective immobilization of ferritin using solid–solution interfacial interactions

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2 Author(s)
Manning, Edward ; Department of Physics and Astronomy, Hunter College of City University of New York, New York, New York 10021 ; Yau, Siu-Tung

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Spatially selective immobilization of ferritin, an iron-storage protein, on a silicon surface using a SiSiO2 template is demonstrated. The material-specific immobilization of the protein is achieved by controlling physical forces at the solution–solid interface between a ferritin solution and the template. The electrostatic interaction and hydrophobic interaction between ferritin molecules and the two kinds of materials of the template can be tuned to achieve adsorption of ferritin only on Si. This method was used to generate spatially confined assemblies of ferritin on the nanoscale and on the micron scale.

Published in:

Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures  (Volume:23 ,  Issue: 6 )

Date of Publication:

Nov 2005

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