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In this study, encapsulating antibiotic loaded titanium alloy by polylactide-co-polyglycolide copolymer (PLGA) for preventing burst releasing and extending antibiotic releasing time will be make for potential future hip prosthesis with deep infection prevention ability. Antibiotics, vancomycin and cefuroxime, were used to measure their temporal release from titanium disc. The result by elution test showed non PLGA coated of antibiotic loaded groups was released at the first hour. For PLGA (85/15) coated groups, vancomycin could still be detected after 5 days, and cefuroxime groups extended the releasing period to at least 7 days.