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Prevention of infection in endotracheal tubes is part of a nationwide effort to reduce the complications associated with patient intubation. By creating nano-rough surfaces on the endotracheal tubes, the adhesion of infectious bacteria can be decreased. Polyvinyl chloride (PVC) endotracheal tubes were treated here with lipases from C. cilindracea and R. arrhisus in an effort to produce such nano-scale surfaces. The surfaces were characterized using scanning electron microscopy (SEM) in order to examine the dimensions of surface features produced after 24 or 48 hours of soaking. After 48 hours, nano structures were clearly observed on PVC in either lipase solution, therefore providing promise to reduce bacterial attachment.