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High-speed digital signal integrity at data rates above 6 Gb/s is an obstacle to reliable serial link operation. Two signal integrity challenges include dispersion due to frequency-dependent losses and reflections created at impedance mismatches. Signal integrity analysis relies on time-domain simulation of pseudo-random data patterns. This paper explores a predictive method for interconnect eye closure caused by reflections at the transmitter and receiver and does not require extensive time domain simulation. Worst-case bounds on intersymbol interference and data-dependent jitter aid prediction for link budgets under channel variations. This method is applied to the design of a passive equalizer.