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A new quality controlled Maxlift and Medlift transforms based compression methods for electrocardiogram (ECG) signal are presented. The ECG signal is transformed using Maxlift and Medlift. The transformed coefficients are thresholded using the bisection algorithm in order to match the predefined user specified percentage root mean square difference (PRD) within the tolerance. Then, the binary lookup table is made to store the position map for zero and non-zero coefficients (NZC). The NZC are quantized by Max-Lloyd quantizer followed by Arithmetic codng. Lookup table is encoded by Huffman coding. The results are presented on different ECG signals of varying characteristics. The results show that Medlift gives better performance as compared to the Maxlift.