By Topic

Activation of Immune Response in Disease Dynamics via Controlled Drug Scheduling

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Hyeygjeon Chang ; Dept. of Electr. & Electron. Eng., Imperial Coll. London, London ; Alessandro Astolfi

The human immunodeficiency virus (HIV) infection, that causes acquired immune deficiency syndrome (AIDS), is a dynamic process that can be modeled via differential equations. The primary goal of this paper is to introduce a control philosophy to boost the response of the immune system by means of drug scheduling. The control purpose is to steer the system to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected patient that does not develop the symptoms of AIDS. The feasibility of the control methodology is illustrated via simulations on two HIV dynamic models and on a general disease model.

Published in:

IEEE Transactions on Automation Science and Engineering  (Volume:6 ,  Issue: 2 )