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Simulating Biological Pathways with a Continuous Petri Net Using Runge-Kutta Methods

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5 Author(s)
Sunku Kang ; Samsung Dept. of Comput. Sci., Sogang Univ., Seoul ; Byungwoo Lee ; Jihoon Yang ; Seonho Kim
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The application of Petri nets to analyze and simulate biological pathways has been developed vigorously. Some of the modifications of Petri nets appeared to perform quantitative analysis of biological pathways: hybrid Petri net, timed Petri net, stochastic Petri net and so on. For a quantitative analysis of biological pathways, we propose to adopt Runge-Kutta methods to act on a continuous Petri net. We show that Runge-Kutta methods are applicable to a continuous Petri net in glycolysis and apoptosis pathways with reliable and efficient simulation results.

Published in:

Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007

Date of Conference:

11-13 Oct. 2007