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A low-power and low-noise CMOS OTA-based amplifier which minimises stimulus artefacts (SAs) in electrically evoked compound action potential (ECAP) measurements is presented. The amplifier is to be incorporated into an electrical stimulation epi-retinal vision prothesis ECAP measurement system. The amplifier has four gain settings (50, 60, 70, 80 dB) over a 7.4-9.9 kHz bandwidth, an input-referred noise of 5.6 muVrms (0.1-10 kHz) and consumes only 12.6 muA quiescent current. The amplifier is simulated using a high voltage 0.35 mum CMOS process and demonstrates an excellent tradeoff of key performance measures.