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Preparation of Water-Dispersible and Biocompatible Iron Oxide Nanoparticles for MRI Agent

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3 Author(s)
Yun Tack Lee ; Korea Inst. of Sci. & Technol., Seoul ; Kyoungja Woo ; Kyu-Sil Choi

Highly monodisperse superparamagnetic iron oxide nanoparticles (SPIONs, 7.5 nm gamma- F2O3) were synthesized by thermal decomposition of iron pentacarbonyl and consecutive aeration in organic medium. By treating with a small amount of iron pentacarbonyl, Fe-rich surface has been formed on SPION. Water-dispersible SPIONs (SPION-MPA) were prepared by Fe-S covalent conjugation between Fe-rich SPION and mercaptopropionic acid (MPA) and then, transformed to SPION-MPA-dextran composite by physical adsorption of biocompatible polymer dextran. The hydrodynamic diameter of SPION-MPA-dextran was in the range of 225~237 nm in water. MR contrast and spin-spin relaxation intensity of our SPION-MPA-dextran were similar to those of the commercial products, Ferridex and Resovist.

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Nanotechnology, IEEE Transactions on  (Volume:7 ,  Issue: 2 )