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The mechatronics system is the integration of mechanical, electrical, information, communication and nano/micro level technologies in the design, manufacture and operation of industrial products and processes. Mechatronics system emphasizes the key factors in integration, intelligence, communication functions which includes actuators/sensors, control of mechatronic systems, microelectromechanical systems (MEMS), mechatronic devices, human-machine interface/haptics, embedded computing and software engineering, networked and embedded mechatronics and design/integration methodologies for mechatronic systems etc. Mechatronics on specific engineering systems to which mechatronics play key roles, such as: automotive systems, mobile robots, precision motion control systems, bio-mechatronics, nano/micro manipulation and nano robotics. In this presentation, we will discuss the state-of-the-art of intelligent mechatronics in the macro and nano world and to present recent advances made research results and perspectives of the future development in this multidisciplinary field of intelligent mechatronic systems.