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Boosting Evolutionary Support Vector Machine for Designing Tumor Classifiers from Microarray Data

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4 Author(s)
Hui-Ling Huang ; Department of Information Management, Jin Wen Institute of Technology, Hsin-Tien, Taipei, Taiwan ; Yi-Hsiung Chen ; Dwight D. Koeberl ; Shinn-Ying Ho

Since there are multiple sets of relevant genes having the same high accuracy in fitting training data called model uncertainty, to identify a small set of informative genes from microarray data for designing an accurate tumor classifier for unknown samples is intractable. Support vector machine (SVM), a supervised machine learning technique, is one of the methods successfully applied to cancer diagnosis problems. This study proposes an SVM-based classifier with automatic feature selection associated with a boosting strategy. The proposed boosting evolutionary support vector machine (named BESVM) hybridizes the advantages of SVM, boosting using a majority-voting ensemble and an intelligent genetic algorithm for gene selection. The merits of the BESVM-based classifier are threefold: 1) a small set of used genes, 2) accurate test classification using leave-one-out cross-validation, and 3) robust performance by avoiding overfitting training data. Five benchmark datasets were used to evaluate the BESVM-based classifier. Simulation results reveal that BESVM performs well having a mean accuracy 94.26% using only 10.1 genes averagely, compared with the existing SVM and non-SVM based classifiers

Published in:

Computational Intelligence and Bioinformatics and Computational Biology, 2007. CIBCB '07. IEEE Symposium on

Date of Conference:

1-5 April 2007