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Feedback optimization of fed-batch bioreactors via neural net learning

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2 Author(s)
Chen, Q. ; Dept. of Chem. Eng., Maryland Univ., College Park, MD, USA ; Weigand, W.A.

The problem of feedback optimization of the feed-rate for a fed-batch bioreactor is investigated by a neural network approach. Using the nonlinear mapping ability of neural networks, feedback optimal control can be realized as a nonlinear function of the state variables. A neural network trajectory learning technique is proposed for optimisation of the desired product for a fed-batch bioreactor. A simulation study of cell mass production demonstrates the training of the neural network feedback controller to achieve the production objective. The superiority of a feedback optimization scheme over open-loop optimal control when there is either model or initial condition error is illustrated and discussed

Published in:

Control Applications, 1992., First IEEE Conference on

Date of Conference:

13-16 Sep 1992