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Principles and Design of a Novel Magnetic Force Mechanical Conditioning Bioreactor for Tissue Engineering, Stem Cell Conditioning, and Dynamic In Vitro Screening

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4 Author(s)
Dobson, J. ; Inst. of Sci. & Technol. in Medicine, Keele Univ., Stoke-on-Trent ; Cartmell, S.H. ; Keramane, A. ; El Haj, A.J.

Mechanical conditioning of cells and tissue constructs in bioreactors is an important factor in determining the properties of tissue being produced. Mechanical conditioning within a bioreactor environment, however, has proven difficult. This paper presents the theoretical basis, design, and initial results of a mechanical conditioning system for cell and tissue culture which is based on biocompatible magnetic micro- and nanoparticles acting as a remote stress mechanism without invasion of the sterile bioreactor environment

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NanoBioscience, IEEE Transactions on  (Volume:5 ,  Issue: 3 )