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Ultra-wideband indoor line-of-sight frequency-domain channel measurements have been performed in the 2-6 GHz frequency band using three different transmit/receive antenna combination pairs. The effects of antenna directivity on path loss and multipath propagation in the channel are analyzed extensively for various omnidirectional and directional antenna combinations. A statistical model of the path loss in the channel is presented, in which all path loss exponents result in better than free space loss. The shadow fading experienced in the channel is shown to highly agree with the normal probability assumption. There is a significant reduction in root mean square delay spread when directional antennas are used at the transmitter and receiver or solely at the receiver with respect to an omnidirectional/omnidirectional antenna pair. Finally, a distance-dependent statistical impulse response model of the channel is presented along with simulation results that significantly concur with the measured data.