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Summary form only given. This talk explores what 21st century enterprise must do in order to survive the accelerated changes globally and compete effectively. There are three major aspects that an enterprise needs to follow, namely; 1. have the courage to do the right things, 2. have the capability to do things right; 3. have the will to change. We also discuss the concept of an Enterprise Clinic/spl trade/ as an implementation framework to help developing 21st century enterprises globally.