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A MEMS viscometric glucose monitoring device

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6 Author(s)
Zhao, Y.J. ; Dept. of Mech. Eng., Carnegie Mellon Univ., Pittsburgh, PA, USA ; Davidson, A. ; Bain, J. ; Li, S.Q.
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We report a MEMS device for continuously monitoring glucose levels in diabetics. The device features a micro-cantilever and a semi-permeable membrane, which are integrated with micro-channels forming a miniature device chamber with a volume of 0.4 μl. The sensor is based on affinity binding principles using the Dextran/Con-A system. The glucose concentration is determined by detecting viscosity changes induced by binding of glucose with Con-A through measurement of the cantilever's vibration parameters. The device is capable of measuring physiologically relevant glucose concentrations from 0 to 25 mM with a resolution better than 0.02 mM. The time for the system to reach binding equilibrium is less than 5 minutes in response to changes in glucose concentration.

Published in:

Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on  (Volume:2 )

Date of Conference:

5-9 June 2005