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Active CMOS biochip for time-resolved fluorescence detection

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3 Author(s)
G. Patounakis ; Dept. of Electr. Eng., Columbia Univ., New York, NY, USA ; K. L. Shepard ; R. Levicky

This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 108/cm2, has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.

Published in:

Digest of Technical Papers. 2005 Symposium on VLSI Circuits, 2005.

Date of Conference:

16-18 June 2005