By Topic

Deterministic lateral displacement MEMS device for continuous blood cell separation

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Zheng, S. ; California Inst. of Technol., Pasadena, CA, USA ; Yung, R. ; Yu-Chong Tai ; Kasdan, H.

This work presents a new MEMS device which uses deterministic lateral displacement for the continuous separation of leukocytes (white blood cells) and erythrocytes (red blood cells). By running blood cells in laminar flow through an array of columnar obstacles, deterministic lateral displacement asserts that the path a cell follows is determined by its size. The system consists of PDMS channels with posts on glass slides. An effective separation region of 7 mm by 1.8 mm is achieved on a 1 cm by 1 cm chip. A 420 μm lateral separation was achieved for 5 μm and 10 μm beads. The critical particle size for separation was found experimentally to be 8 μm, concluded from our results using 5 μm, 7 μm, 8 μm and 10 μm polystyrene beads. Diluted whole blood and blood fraction of concentrated leukocytes were also tested with the devices in agreement with blood count results. Problem of blood cell stiction to device surfaces was investigated.

Published in:

Micro Electro Mechanical Systems, 2005. MEMS 2005. 18th IEEE International Conference on

Date of Conference:

30 Jan.-3 Feb. 2005