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A genetic algorithm-based method is presented to model the interconnect discontinuities in multi-Gb/s systems. In the proposed algorithm, only the s11-parameter of a discontinuity is needed. The data can be obtained either from measurements or 3D-electromagnetic simulations. The measurement/simulation results are processed with genetic algorithm optimization technique (GAOT) to compute the values of lumped circuit components that model the discontinuity. Eliminating the need for measurement/simulation and post-processing for all entries of the S-parameter matrix as well as de-embedding, the proposed algorithm improves the computational cost while preserving the accuracy of the model. The results of the algorithm show good agreement to measurements.