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Probing lipid membranes and ion channels with high frequency spectroscopy

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6 Author(s)
Olapinski, M. ; Sekt. Phys., Univ. of Munich, Munchen, Germany ; Bruggemann, A. ; George, M. ; Manus, S.
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A coplanar waveguide defined on a glass chip is integrated within a microfluidic cartridge to allow for high-frequency testing of lipid bilayer membranes. The membranes are carefully deposited on the circuit using a solvent exchange method or, alternatively, vesicle fusion. The quality of the lipid bilayer membranes is controlled by fluorescence microscopy and scanning probe techniques. The deposition of the bilayers results in a significant change in the high frequency transmission properties of the circuit. We also embed alamethicin, a model ion channel forming peptide, in the bilayers in order to quantify the influence of channel charging events on the overall impedance.

Published in:

Nanotechnology, 2004. 4th IEEE Conference on

Date of Conference:

16-19 Aug. 2004