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Bones are now considered as a well accepted series of piezoelectric materials. Several researchers have used the bone material to develop piezoelectric sensors for the measurement of pressure, force, acceleration and other such parameters. However, with the advancement of technology in sensor systems, micro and nano-scale devices are now being developed by using semiconductor or biological materials, all over the world. Bio-chips based on DNA, and bio-MEMS, etc are some of the examples. In this present research, new bone chips have been developed for various sensor applications, mainly micro or nanoscale systems. Design and fabrication aspects of the bone sensor chips for nano-transducers are discussed in detail here. Possible biomedical applications of these chips are also given in brief.