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This paper proposes a novel time alignment control (TAC) for uplink dynamic parameter controlled orthogonal frequency and time division multiple access (DPC-OF/TDMA), which has been suggested for development of new generation mobile communication system. The purpose of the proposed TAC is reducing an influence of multiple access interference (MAI) by propagation delays (PDs) due to differences of distances between accessing mobile stations (MSs) and an access point (AP). The proposed TAC estimates PDs of all MSs and informs the estimates to them. MSs accessing to AP control their transmission timings according to the informed estimates and compensate PDs. This paper examines the uplink DPC-OF/TDMA with the proposed TAC in term of slot error rate (SER) performances by computer simulation. The result shows that the proposed TAC performs precisely to compensate PDs, and that the uplink DPC-OF/TDMA with proposed TAC enables an equivalent performance to an ideal one under no PDs condition.