By Topic

Temporally invariant uniform spatial resolution in dynamic PET

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
E. Asma ; Signal & Image Process. Inst., Southern California Univ., Los Angeles, CA, USA ; R. M. Leahy

We investigate methods for obtaining uniform spatial resolution over the entire scan duration for penalized ML dynamic PET image reconstructions. We approximate the true continuous time log-likelihood function by a bin-mode log-likelihood, which is obtained by dividing the scan duration into multiple constant-width bins and expressing the likelihood of the total number of counts in each spatiotemporal bin. We then exploit the space-time separability of the bin-mode imaging equation using Kronecker products and derive approximate expressions for two types of local impulse response (LIRs). The first type of LIR is defined as the derivative of the mean reconstructed dynamic PET image to a perturbation to the coefficients of the temporal basis functions. The second LIR definition involves the derivative of the mean reconstructed image to a spatiotemporal impulse which falls outside the temporal model. Temporally invariant uniform spatial resolution can be achieved under the first LIR definition by scaling both spatial and temporal hyperparameters by the diagonal entries of the dynamic Fisher information matrix (FIM). Under the second definition this scaling ameliorates the non-uniform resolution, however further modifications are necessary. We conclude with simulation results.

Published in:

Nuclear Science Symposium Conference Record, 2003 IEEE  (Volume:5 )

Date of Conference:

19-25 Oct. 2003