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A time domain procedure is proposed to analyze by CAD circuit simulators the voltage and current wave propagation in shielded cables taking into account frequency-dependent losses. First, the line is discretized in a series-cascade of line sections. Second, each line section is modeled by a two-port network with lumped time-constant parameters obtained by applying the vector fitting technique. The series-cascade circuits are then analyzed by CAD circuit simulators. The obtained results are compared with those obtained by measurements and by the frequency domain solution of the transmission line equations.