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The high speed implementation of a DFE (decision feedback equalizer) requires reformulation of the DFE into an array of comparators and a multiplexer loop. The throughput of the DFE is limited by the speed of the multiplexer loop. This paper proposes a novel look-ahead computation approach to pipeline multiplexer loops. The proposed technique is demonstrated and applied to design multiplexer loop based DFEs with throughput in the range of 3.125-10 Gbps.