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This paper presents adaptive downlink multi-carrier resource allocation strategies based on channel information suitable for real-time multimedia services in mobile cellular systems. Both user quality-of-service (QoS) and system performance in terms of system spectral efficiency are considered in the evaluation and comparison of the proposed schemes. Simulation results show that by employing the time-varying channel responses to arrange and allocate the sub-carriers according their expected signal-to-noise ratio (SNR) quality, the proposed scheme offers a substantial increase in system spectral efficiency in supporting real-time multimedia services of different QoS requirements. Interference avoidance strategies are also introduced to further enhance the performance of voice services in cellular systems.