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PCR-slide: a modular and cascadable platform for DNA sample processing with integrated nanolitre dosage

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5 Author(s)
Kaack, R.M. ; IMTEK, Freiburg Univ., Germany ; Jung, A. ; Wenz, H.M. ; Zengerle, R.
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For the first time we present a novel DNA sample processing platform with an integrated nanolitre dosage unit for extraction of processed materials in nanolitre quantities. A unique feature of the new platform is the possibility to link several sample processing steps including dilution/titration without any need for external pipetting equipment except for sample loading. This has been demonstrated by using the oligonucleotide ligase assay (OLA) coupled to the polymerase chain reaction (PCR), a sequence which requires a 1:15 dilution of OLA in PCR.

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Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS)

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